Profession

A character isn't always just an adventurer, lest being a mercenary is their only goal. Many will have a side profession or even main profession they are good at. These professions can have many, many uses and should be utilized by a DM to a good end. There are a lot of skills that pair with a profession, in which case the profession check should be used and the DC should be reduced by 5. The amount of professions is legion, so I will only list a few as examples and how they could be used.

Bounty Hunter

A combination of useful skills coalesced into the general skill that can be used for the tracking and apprehension of criminals. This profession can be used in place of several skills so long as it pertains to the tracking and capture of a bounty hunter's target. For example, if tracking their target using foot-prints, things left behind, who they've spoken to, etc. A Profession (Bounty Hunter) roll can be used in place of Bushcraft or Gather Information. For the restraint of a criminal, this skill can be used in place of use rope. Every 5 skill points of Bounty Hunter will grant a +1 competency bonus on offensive grapple rolls, but not defensive uses of it.

Locksmith

You are skilled not just in lock picking but the assembly, repair, and manufacturing of locks as a whole. Picking a lock to you is a request from a customer or a government worker. Your locks are also legendary. With the use of a Tinker's work bench you can create locks of a DC equal to your Profession check when rolling. This skill will also grant a +2 synergy bonus to lock picking with 6 or more skill points in it. This skill can be used in place of a lock picking check, whatever the DC of the check was it will be reduced by 5.