Lock Picking
Keys aren't always the best way into a box, and sometimes there isn't one available. A good set of probes, rakes, picks, and tension bars can go a long way. Most DCs are preset by a DM for an object. It is possible for opposed rolls against locks made by a person with the profession (Locksmith) skill. Lock picking takes 1 minute per attempt and cannot be rushed. Rolling 10 less than the DC will break the lock pick.